MOOH

Oral Health,
Clearly Revealed

Your oral microbiome is one of the most complex bacterial ecosystems in your body. To understand it accurately, you need a method that can capture its full diversity.

Next-Generation Sequencing (NGS) does exactly that. It analyzes all bacterial DNA in your sample, creating a detailed molecular snapshot of your oral microbiome. This allows us to identify known, rare, and even previously unrecognized bacteria with high precision.

Our Next-Generation Sequencing test detects up to 16x more bacterial species than traditional PCR tests [1]. While PCR (Polymerase Chain Reaction) searches for only a small set of predefined microbes, NGS analyzes your entire oral microbiome – comprehensive, precise, and unbiased.

We capture the full
picture –
not just fragments

More than 700 bacterial species live in the mouth [2]. Many of them cannot be detected with conventional testing methods.

PCR works like a checklist: You only find what you search for. Studies show: NGS identified 177 species, PCR only 25 [1]. It also detected far more resistance genes (34 vs. 7) [1].

Your data becomes
more valuable over time

NGS provides a complete molecular snapshot that can be reanalyzed at any time – even years later – as new scientific insights emerge.

RESEARCH IS ADVANCING RAPIDLY:
63% of newly described bacterial species were previously unknown [3], and over 74 million new genes have been identified [3].

Your data stays relevant:
it can be revisited DIGITALLY
without new sampling.

We also detect the unexpected

NGS can reveal findings no one thought to look for. A striking example comes from cancer research:

When researchers analyzed colorectal tumors with NGS in 2012, they unexpectedly discovered large amounts of the oral bacterium Fusobacterium nucleatum [4]. Until then, this bacterium was known mainly for its role in gum inflammation. Its presence in tumors of a completely different organ was surprising – and would not have been detected by PCR.

This discovery showed for the first time that oral bacteria can play a role in diseases far beyond the mouth. This is why comprehensive, unbiased analysis is so essential.

Why PCR falls short

PCR is like shining a flashlight into the night sky – you only see the small area you're looking at. NGS reveals the entire universe of your oral microbiome.

PCR relies on primers – short DNA sequences designed to match only specific bacteria. Even a single mismatched primer can lead to 4-10x measurement errors [5].

And with more than 700 bacterial species living in the mouth, PCR simply cannot capture the full picture. It typically detects only 5-20 predefined species, leaving the vast majority of your microbiome unseen.

The link to overall health

Your oral microbiome is connected to:
– Respiratory diseases
– Cardiovascular conditions
– Diabetes
– Inflammatory bowel disease

A 2024 study found that saliva provides particularly valuable diagnostic information, even for diseases in distant organs [6].

A 2025 study showed that oral microbiome samples often reveal stronger disease-related signals than stool samples, for example in obesity [7].

Know your oral microbiome –
and care for it today
and tomorrow

The evidence is clear: NGS offers the most comprehensive, precise, and future-proof analysis of the oral microbiome.

– 16x more detected bacterial species [1]
– Future-ready data that can be reanalyzed anytime
– Complete, unbiased insights
– Detects unexpected associations

PCR shows only a small part.
NGS reveals the full picture – today and in the future.

All statements are supported
by peer-reviewed scientific studies

[1] Dave M, Tattar R. (2025). Antimicrobial resistance genes in the oral microbiome. Evidence-Based Dentistry, 26(1), 42-43. [DOI: 10.1038/s41432-025-01120-z](https://doi.org/10.1038/s41432-025-01120-z)

[2] Deo PN, Deshmukh R. (2019). Oral microbiome: Unveiling the fundamentals. Journal of Oral and Maxillofacial Pathology, 23(1), 122-128. [DOI: 10.4103/jomfp.JOMFP_304_18] (https://doi.org/10.4103/jomfp.JOMFP_304_18)

[3] Sun Y, Chen Q, Fan G, et al. (2025). gcMeta 2025: a global repository of metagenome-assembled genomes. Nucleic Acids Research, gkaf1115. [DOI: 10.1093/nar/gkaf1115] (https://doi.org/10.1093/nar/gkaf1115)

[4] Castellarin M, Warren RL, Freeman JD, et al. (2012). Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Research, 22(2), 299-306. [DOI: 10.1101/gr.126516.111] (https://doi.org/10.1101/gr.126516.111)

[5] Parada AE, Needham DM, Fuhrman JA. (2015). Every base matters: assessing small subunit rRNA primers for marine microbiomes. Environmental Microbiology, 18(5), 1403-1414. [DOI: 10.1111/1462-2920.13023] (https://doi.org/10.1111/1462-2920.13023)

[6] Schmartz GP, Rehner J, Gund MP, et al. (2024). Decoding the diagnostic and therapeutic potential of microbiota using pan-body pan-disease microbiomics. Nature Communications, 15, 8261. [DOI: 10.1038/s41467-024-52598-7] (https://doi.org/10.1038/s41467-024-52598-7)

[7] Gund MP, Luukkonen PK, Lunken GR, et al. (2025). Joint bacterial traces in the gut and oral cavity of obesity patients provide evidence for saliva as a rich microbial biomarker source. Nutrients, 17(22), 3527. [DOI: 10.3390/nu17223527] (https://doi.org/10.3390/nu17223527)

OUR PRODUCTS ARE COMING SOON. THE NGS TEST AND ORAL PROBIOTICS WILL BE AVAILABLE SHORTLY. STAY TUNED.